BAKUCHIOL: “THE PLANT-BASED POWERHOUSE FOR YOUTHFUL SKIN’’

Pharmacy

A meroterpene phenol with promise anti-aging, anti-inflammatory, and antibacterial qualities, bakuchiol has attracted a lot of interest in the cosmetics business. This review paper offers a thorough analysis of bakuchiol's topical application, emphasizing its physicochemical characteristics, sources, bioactivities, nanotechnology delivery methods, and toxicological and regulatory issues. The main source of bakuchiol is the seeds of the Asian natural medicinal plant Psoralea corylifolia. But because of its poor seed germination rates and high seedling mortality, this plant is vulnerable. The review covers methods for reviving plants from fragments of roots as well as ways to confirm the legitimacy of the plant and stop fakes. Bakuchiol has antifungal, antibacterial, antioxidant, anti-inflammatory, antiaging, depigmenting, and anticancer properties that are the principal skin bioactivities. Bakuchiol is a promising substitute for topical retinoids because it has been demonstrated to have retinol-like effects on gene expression. Research conducted in vivo has indicated noteworthy decreases in photodamage, hyperpigmentation, wrinkles, and acne severity when bakuchiol is used either by itself or in conjunction with other products. The development of novel bakuchiol skin delivery methods, including micro- and nano-sized systems for medical and cosmetic uses, is also covered in the review. These delivery methods seek to strengthen bakuchiol's transdermal distribution and its physicochemical characteristics. Lastly, taking into account user safety as well as the influence on the environment, the paper discusses regulatory challenges, metabolic considerations, and toxicological concerns associated to the use of bakuchiol in cosmetic and dermo pharmaceutical formulations. As a result, readers will have a thorough understanding of the potential of bakuchiol as a natural retinol-like component in medicinal and cosmetic applications for skin health and youthfulness.

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