DEVELOPMENT AND CHARACTERIZATION OF ORAL MICRO-PARTICULATE DRUG DELIVERY SYSTEM

Pharmacy

The development and characterization of oral micro-particulate drug delivery systems are great strides in pharmaceutical science. This approach had thus been directed toward the improvement of the bioavailability of drugs and their therapeutic effects. The micro-particulate systems in question, which are mostly microparticles or microspheres, exhibit both controlled and sustained release of APIs, thus improving the patients' compliance by reducing dosing frequencies. These systems safeguard drugs from the gastrointestinal problems. Development is based on the selection of appropriate polymers and excipients that form the microparticles containing the active principle suitably entrapped within the matrix. Various methods, such as spray drying, solvent evaporation, and coacervation, can be employed for the preparation of these microparticles. Each of these techniques offers various advantages concerning particle size, drug-loading efficiency, and release profiles. The characteristics of the micro-particulate system are highly important, whereby techniques involve particle morphology through scanning electron microscopy, thermal properties through differential scanning calorimetry, and in vitro dissolution testing through release kinetics. Micro-particulate systems can also be engineered to deliver drugs in a site-specific manner that minimizes systemic side effects and optimizes therapeutic outcome.

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