Composition and Analyzation of Transdermal Diclofenac Sodium Patches

Pharmacy

Transdermal patches are gaining prominence as an alternative to oral drug delivery, offering controlled release and improved patient compliance. This study focuses on the composition and analysis of transdermal patches containing Diclofenac Sodium, a non-steroidal anti-inflammatory drug (NSAID) used for pain and inflammation management. The patches were formulated using various polymers, including hydroxypropyl methylcellulose (HPMC) and polyvinyl alcohol (PVA), alongside plasticizers like glycerin and enhancers such as propylene glycol to ensure optimal drug release and skin permeability. The patches were prepared via solvent casting and characterized for their physicochemical properties, including thickness, weight uniformity, drug content, moisture content, and tensile strength. In vitro drug release studies were conducted using Franz diffusion cells, while Fourier-transform infrared spectroscopy (FTIR) was utilized to assess drug-polymer interactions. Results indicated that polymer composition significantly influenced the drug release profile, with an ideal balance between film flexibility and sustained drug release. The study concluded that transdermal Diclofenac Sodium patches present a viable method for controlled drug delivery, offering consistent drug release over time with minimal side effects. The formulation and evaluation process underscores the importance of optimizing polymer types and concentrations for effective transdermal therapy.

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