Validation of Sitagliptin Phosphate & Simvastatin by RP-HPLC

Pharmaceutical Science

The importance of antidiabetic drugs are increasing day by day generally Sitagliptin phosphate is a highly selective DPP-4 inhibitor that is thought to act in type 2 diabetes by slowing the inactivation of incretin hormones and Simvastatin increases the rate at which the body removes cholesterol from blood by HMG-CoA reductase inhibition. So, both of these drug in combination are used for method development by RP- HPLC. Few analytical techniques are reported for STG and SMV out of which many of these are time consuming, affecting column life and costly. So this research work is dedicated to develop and validate simple, efficient, economical, fast, reliable new method for Simultaneous estimation of STG and SMV in bulk and pharmaceutical dosage form by RP- HPLC. In this method analytical technique of Reverse Phase High Performance Liquid Chromatography (RP-HPLC) was used for quantitative determination of Sitagliptin Phophate & Simvastatin was used. The mobile phase used was Methanol : Water (90:10)

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