Formulation and evaluation of topical antimicrobial and oral Antiulcer gel from liquorice extract

B pharmacy

This project is designed to develop licorice root into a herbal product and investigate its antimicrobial properties against various types of bacteria, including Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa), and C. albicans, a species of yeast. Another property is antiulcer like mouth ulcer. It often causes pain and discomfort and may change the patient's food choices during treatment. The two most common types of mouth sores are localized sore throat and aphthous stomatitis. Canker sores are small, painful sores that usually have red edges and yellow-gray areas. Mouth ulcers can be treated with antibiotics, and corticosteroids, and there is also a way to treat mouth ulcers using herbs derived from the licorice plant. Different extract concentrations. All prepared formulations have physical and chemical properties, choosing good appearance and consistency, permeability, recommended pH and physiological compatibility of the skin. The selected method was also characterized by examining the in vitro antimicrobial activity and antiulcer activity. The results showed that licorice gel could be successfully made using Carbopol 934 as the gelling agent and the selected samples showed good antimicrobial activity against Staphylococcus aureus and Candida albicans, but not antibiotic against it. Pseudomonas aeruginosa. Therefore, the preparation of licorice topical gel can be considered a good alternative to antimicrobial in herbal medicine. The purpose of this study is to turn licorice into gel and to examine whether licorice is effective in the treatment of oral diseases. Moreover, the results showed that the prepared licorice gel had good stability at room temperature and there was no significant difference after four months of storage (p≤0.05). A new herbal herbal antibiotic ointment gel formulation candidate has been proposed to enter the market.

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