Formulation and evolution of Aspirin buccal patches for Antiplatelet Use

Pharmacy

Extensive research efforts have recently been focused on placing a drug delivery system in a particular region of the body for maximizing biological drug availability and minimizing dose-dependent side effects. Buccal delivery of drugs provides an attractive alternate to itother conventional methods of systemic drug administration, since buccal mucosa is relatively permeable with rich blood supply and acts as an excellent site for the absorption of drugs .The buccal patches of Aspirin were prepared by using solvent casting method. Weighed accurately amount of polymer Dispersed in a beaker containing distilled water with stirring on magnetic stirrer. Add Poly ethylyne glycol (PEG)-400 to the polymeric solution during addition of plastisizer continuous stirring is necessary to prevent lump formation. Weigh accurately amount of Aspirin and dissolve in distilled water which gives the suspension of Aspirin. Add the Aspirin suspension to the solution of polymer and plastisizer with continuous stirring. FT-IR spectra for pure nitroglycerin and Different polymers acquired at room temperature using FT-IR spectrophotometer in transmittance mode. The samples were ground in a mortar, mixed with Nujol and placed between two plates of KBr and compressed to form a thin film. The sandwiched plates were placed in the infrared spectrometer and the spectra were obtained. Scanning was performed between wave numbers 4000-400 cm-1.

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