RECENT PERSPECTIVES OF THIAZOLIDINE-2,4-DIONES AS ANTIBACTERIAL ANTIFUNGAL AGENTS AND ANTIOXIDANT ACTIVITY

M. Pharmacy (Pharmaceutical chemistry)

The widespread presence of nitrogen- and sulfur-containing heterocyclic compounds in pharmacologically dynamic natural products and as overwhelmingly powerful agrochemicals and pharmaceuticals has piqued interest in their synthetic chemistry. The thiazolidine-2,4-dione (TZD) moiety is crucial to the operation of several vital molecules. The TZD scaffold is extensively employed and adaptable due to the availability of substitutions at the third and fifth positions, allowing for a broad variety of biological activities to be shown by this moiety. The antibacterial activity of TZD analogues is shown by the suppression of cytoplasmic Mur ligases. In this publication, we attempt to summarize the literature on TZD derivatives as prospective antibacterial agents from the beginning of 2012 to the end of 2022, including a discussion of their molecular mechanisms and details on patents awarded to TZD analogs.

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