FORMULATION AND EVALUATION OF TOPICAL GEL OF DICLOFENAC DIETHYLAMINE

Bechlor of pharmacy

In order for the pharmacological action of a topical dermal drug product to occur, the drug must first be released from the vehicle to be available to penetrate the skin layer and reach the site of action. Drug release is mainly dependent on the characteristics of the formulation. It is phenylacetic acid derivatives developed as anti-inflammatory agent. It has analgesic anti-inflammatory antipyretic like actions like other NSAIDS. It is recommended in long term treatment of rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. It is also useful acute musculoskeletal disorder post operative pain and dysmenorrhea. Diclofenac di-ethylamine gel was developed in five different formulation(F1 to F5) by employing different grades of polymers such as Carbopol 934 and Carbopol 1940.The gel was prepared and evaluated for pH, spreadability, consistency, homogeneity and viscosity. The Carbopol is high molecular weight water soluble homo polymer which posses high viscosity in low concentrations, transparency, and film forming properties these are useful for gel formation. The present study suggests that the Diclofenac di-ethylamine effectively act as invitro anti-inflammatory activity. Finally the gel formulations found to be economical and may overcome the draw backs associated with the drug during its absorption.

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