TRANSDERMAL DRUG DELIVERY SYSTEM: AN OVERVIEW

Pharmaceutical science

Transdermal drug delivery systems (TDDS) have gained increasing importance in the field of pharmaceuticals due to their potential to provide controlled and sustained release of drugs with improved patient compliance and reduced side effects. This review offers a comprehensive exploration of TDDS, covering the principles, components, and formulation strategies involved in their development. We delve into the intricacies of skin anatomy and physiology as they relate to drug permeation, highlighting the critical factors influencing successful transdermal drug delivery. Additionally, we discuss the role of permeation enhancers, novel materials, and emerging technologies in optimizing TDDS performance. The review also underscores the significance of mathematical modeling and computational simulations in TDDS design and optimization. Furthermore, we examine the challenges and breakthroughs in delivering macromolecules and biologics via transdermal routes, along with emerging applications such as personalized medicine. Case studies and examples provide real-world insights, and we conclude by discussing future research directions and the evolving landscape of transdermal drug delivery. This review aims to serve as a valuable resource for researchers, clinicians, and pharmaceutical scientists, offering a comprehensive overview of the field and insights into its promising future.

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