Formulation and evaluation of anti-inflammatory and analgesic herbal ointment

Pharmaceutics

The present study was aimed to developed formulation on the anti-inflammatory, & Analgesic activity of Punicagranatum peels waste. Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with too much side effects and adverse drug reactions. Constant used of NSAIDs produces gastrointestinal irritation and other side effects on body organs like liver and kidneys. Anti-inflammatory & Analgesic activity of Punicagranatum peel extract was previously reported on different experimental models. Generally pomegranate peels are waste material obtained from many pomegranate processing industries. These peels consists important polyphenols, flavonoids & β-sitosterol as an active chemical constituents which is useful in the inflammation. Inflammation is associate with pain, readness & swelling. Flavonoids shows antioxidant activity with indirect inhibition of inflammatory markers such as tumor necrosis factor alpha. Analgesic activity of punicagranatum peels is useful in the management of pain. Ointment formulation of punicagranatum peel shows a good result in all the evaluation test parameters such as General appearance, Consistency, pH, Spreadability, Extrudability, Diffusion study, Non irritancy test, & Stability study etc.

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