Evaluation of therapeutic effect of a Polyherbal formulation on Urinary Retention and Urinary Tract Infection in Experimental Animal Model

Pharmacology

Ethnopharmacological relevance A variety of urological conditions, including urine retention, incontinence, urinary tract infections, and bladder stones, may arise in eunuchs after castration. Treatment for chronic conditions like urinary tract infections (UTI) with traditional Chinese medicine (TCM) offers a number of definite advantages. Benign Prostatic Hyperplasia (BPH) has been therapeutically treated in China for many years using the Qianliening capsule (QC), a formulation of traditional Chinese medicine. However, no research work has been done on the use of QC for the treatment of Urinary Retention and Urinary Tract Infection in Castrated Animal Model. Aim and objectives of the study Aim:To evaluate the therapeutic effect of a Polyherbal formulation on Urinary Retention and Urinary Tract Infection in a castrated Experimental Animal Model. Objectives: To find out a new herbal drug treatment option for the Urinary Retention and Urinary Tract Infection in a castrated animal model. To understand the incidence of Urinary Retention and Urinary Tract Infection in castrated animal model. Materials and methods Castration and penectomy was performed on all rats. After 8-10 days of healing period, the body temperature, and 24 hour micturition frequency and total urine output (voiding behavior) was recorded for all rats. Increased micturition frequency and reduced urine output confirmed the presence of Urinary Retention in all rats. Biochemical indicators related to UTI and rise in body temperature confirmed the urinary tract infection induced by urinary retention. The treatment protocol lasted for 7 days for standard, control and QC (2.25gm/Kg, 4.5gm/Kg and 9gm/Kg) groups. The effects of QC over voiding behavior and urinary tract infection induced by urinary retention were evaluated. Results After treatment with different doses of QC (2.25gm/Kg, 4.5gm/Kg and 9gm/Kg), the biochemical indicators related to UTI like urine WBC count, pH and nitrite count were reduced. Body temperature was also improved upon treatment with QC. All QC groups showed dose-dependent improvement in the turbidity of urine. In case of voiding behavior study, 24 hour micturition frequency and total urine output was improved significantly only in the 9gm/Kg QC group. Conclusion QC has a remarkable therapeutic impact on UTI in castrated rats induced by urinary retention. The information offered in this study establishes the groundwork for future research into the treatment of UTI in the special population (Eunuchs) and offers a novel concept and approach.

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