A REVIEW ON: THE DIFFERENT BENZIMIDAZOLE DERIVATIVES ACTIVITIES IN THE DIAGNOSIS AND TREATMENT OF DISEASES

Department of Pharmaceutical Chemistry (M.pharm)

This review's main goal is to provide the results of studies on the benzimidazole derivative. Benzimidazole derivatives were created and tested for cytotoxicity and antiviral activity against a panel of ten RNA and DNA viruses in cell-based experiments. Also review on antifungal activity of selected benzimidazole compounds and synthesis and antimicrobial activity of some new benzimidazole derivatives. More recently, selected benzimidazole derivatives were shownto be active in vitro against two protozoan parasites, Trichomonas vaginalis and Giardia lamblia, and clinical studies with AIDS patients have suggested that microsporidia are susceptible as well. The benzimidazole methylcarbamate drugs, commonly used as anti-helmitics, have been suggested to have anticancer activity, but progress has been stalled by their poor water solubility and poor suitability for systemic delivery to disseminated cancer. The in vitro effects of novel benzimidazole derivatives with thiosemicarbazide and triazole moieties at the N1 position on rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels were determined by measuring the formation of 2-thiobarbituric acid reactive substance. Overview on the anti-diabetic studies of novel benzimidazole-pyrazoline hybrid molecules and and anti-inflammatory evaluation of novel benzimidazole derivatives.

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