A REVIEW ON: FLOATING DRUG DELIVERY SYSTEM

Pharmacy

The oral route is the most appropriate and widely used for the delivery of drugs to the systemic circulation. This route has high acceptability for patients, particularly due to the ease of administration. Over the years oral dosage forms have become increasingly world-wise in the pharmaceutical field, with controlled release drug delivery systems that release the drug at a predetermined rate playing a major role. Various approaches have been designed and utilized to achieve efficient drug delivery for those drugs that have poor bioavailability and shorter gastric residence time. On the other hand floating drug delivery system, one of the most extensively used approaches of the Gastro retentive drug delivery system has an advantage for the drugs that are absorbed primarily in the upper segments of the Gastrointestinal tract i.e., stomach, duodenum, and jejunum. The types of floating drug delivery systems, the principle, and mechanism of floating action to achieve gastric retention. The In-vitro and In-vivo studies used to evaluate the potential, performance, and application of floating systems in to overcome various problems encountered during the development of a dosage form innovative drug delivery technologies are being used and are available for clinical use. Floating Drug Delivery Systems (FDDS) is one of the gastro- retentive dosage forms used to achieve extended duration of gastric residency. Floating drug delivery systems (FDDS) was to compile the recent literature with particular focus on the main floating mechanism to achieve gastric retention. Sustained oral release of gastrointestinal dosage types provides many benefits for drugs with absorption from the upper sections of the gastrointestinal tract and those that function locally throughout the stomach. The physiology, factors controlling gastric retention time, excipient variables influencing gastric retention, approaches to designing single-unit, hydro-dynamically balanced system and multi-unit floating structure, and aspects of their classification, formulation and evaluation.

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