FORMULATION AND EVALUATION OF FAST DISSOLVING FILMS OF OLOPTADINE HCL

PHARMACY

Our studies on the performance of formulation and evaluation of fast dissolving films of Olopatadine HCL its anti-allergic drug. Prepare mouth dissolving film of Olopatadine HCl by solvent casting method. To characterize the prepared mouth dissolving film of Olopatadine HCL in terms of— Thickness, percent elongation, tack test, swelling index, in-vitro disintegration time and dissolution test. Olopatadine OLO), 11-[{z}-3-(Dimethlamino) propylidene]-6-11-dihydrobenz [b, e] oxepin-2-acetic acid hydrochloride, is widely used as an antihistaminic. Olopatadine HCL is a relatively selective histamine H1-receptor antagonist that inhibits the release of histamine from mast cells. Olopatadine does not affect alpha-adrenergic dopamine, muscarinic type 1 and 2 or serotonin receptor. They are hydrophobic in nature and non-polar, sparingly soluble in water and freely soluble methanol, ethanol. Olopatadine HCl is a mouth dissolving film. We is trying to sort out the problem of allergic. They are rapidly onset of action, when placed upon the tongue that it is disperse rapidly swallowing within 3-5 seconds without need of water or chewing.

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