DESIGN, DEVLOPMENT AND EVALUATION OF CAPTROPRIL MICROSPHERE BY IONOTROPIC GELATION METHOD`

Pharmaceutical Sciences

For a considerable amount of time, research has focused on the development of an oral sustained or controlled release dosage form of captopril.difficulties encountered because the medication is readily soluble in water.Due to its effectiveness and widespread use as the drug of choice in the treatment of hypertension and congestive heart failure, numerous sustained and controlled release formulations of captopril have been developed and reported. However, it is difficult to deliver such a drug orally in a sustained or controlled release manner.Captropril microspheres were made by using an ionic cross-linking technique with CaCl2 and a coat of alginate and polymers like HPMC, sodium alginate, and soda carboxymethyl cellulose.

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.