DEVELOPMENT AND IN VITRO CHARACTERIZATION OF CLARITHROMYCIN MICROSPHERES

PHARMACEUTICAL SCIENCES

In the present work, bioadhesive microspheres of Clarithromycin using Sodium alginate along with HPMCK100M, HPMCK15M, as copolymers were formulated to deliver Clarithromycin via oral route. The results of this investigation indicate that ionic cross linking technique Ionotropic gelation method can be successfully employed to fabricate Clarithromycin microspheres. The technique provides characteristic advantage over conventional microsphere method, which involves an “all-aqueous” system, avoids residual solvents in microspheres. Other methods utilize larger volume of organic solvents, which are costly and hazardous because of the possible explosion, air pollution, toxicity and difficult to remove traces of organic solvent completely. Micromeritic studies revealed that the mean particle size of the prepared microspheres was in the size range of 512-903µm and are suitable for bioadhesive microspheres for oral administration.Increase in the polymer concentration led to increase in % Yield, % Drug entrapment efficiency, Particle size, % swelling and % Mucoadhesion.The in-vitro mucoadhesive study demonstrated that microspheres of Clarithromycin using sodium alginate along with HPMCK15M as copolymer adhered to the mucus to a greater extent than the microspheres of Clarithromycin using sodium alginate along with HPMCK100M as copolymer.

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.