Design and Development of Atenolol Orally Disintegrating Tablets by Superdisintegration Method

Pharmacy

The present study aims to formulate and evaluate oro dispersible tablets of Atenolol, a drug that is used for the treatment of chest pain (angina) was prepared by using superdisintegration method and also optimize the best formulation. The study involved different excipients which were tested for their compatibility with Atenolol by the FT-IR studies. Based on the results of FT-IR studies, majority of the excipients were found to be compatible with Atenolol which were used for the preparation of Atenolol oral disintegrating tablets. Oral disintegrating tablets of Atenolol were prepared by direct compression method by the addition of super disintegrants. Seven batches (F1 – F7) of oral disintegrating tablets of Atenolol were prepared by using super disintegrants like Sodium starch glycolate and Croscarmellose in variable concentrations along with other excipients for the development of optimized formulation. All the formulations were subjected to evaluation studies of weight variation, hardness, friability, drug content, Wetting time, in-vitro disintegration, in vitro-dissolution studies and are found to be within the limits.

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