Formulation & Evaluation of Ciprofloxacin Controlled Release Floating Capsules

Pharmacy

Capsules are solid preparations in which the drug substances and/or excipients are enclosed in either a soft or hard soluble shell. The shell is normally made of gelatin or suitable polymeric material and results in a simple, tasteless, odourless, elegant, easy to swallow dosage form without the need for a secondary coating step. Controlled release dosage forms have attracted considerable interests as a mean of improving the dissolution rate & hence possibly bioavailability range of hydrophobic drugs. The poor solubility of ciprofloxacin leads to poor dissolution & hence variation in bioavailability. The purpose of present investigation was to formulate and evaluate controlled release floating capsules of ciprofloxacin with improved solubility & dissolution rate. In present study granules using various carriers like mannitol & lactose in different ratios were prepared by wet granulation method using polymer such as ethyl cellulose & HPMC. The prepared granules were evaluated to preformulation studies such as angle of repose (18.41-24.22), bulk density, tapped density, compressibility index (11.31-12.75) & hausner’s ratio. All the parameters shows that the granules having good flow properties. These granules had converted into the capsule forms. Then the formulated capsules were taken to the evaluation studies such as weight variation, release study, buoyancy & floating duration (more than 6 hrs.). We can conclude that all the parameters were within the acceptable limits.

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