Formulation and Evaluation of Sustained Release Tablets of Losartan Potassium

July 2022
Vol-8, Issue-4
Paper ID: 17697
ISSN: 2395-4396
Downloads: 0

Abstract & Details

Research Area
Pharmacy
Keywords
Losartan potassium Sustained release ethyl cellulose in-vitro drug release and anti- hypertensive drug
Abstract
The present study was undertaken to develop sustained release (SR) tablets of Losartan potassium, an angiotensin-II antagonist for the treatment of hypertension. The tablets were prepared by wet granulation method, with ethyl cellulose. The amount of Losartan potassium remains fixed (100 mg) for all the six formulations whereas the amounts of ethyl cellulose were 50mg,60mg,70mg,80mg,90mg and 100mg for F-1, F-2, F-3, F-4, F-5 F-6 & F7 formulations respectively. The evaluation involves three stages: the micromeritic properties evaluation of granules, physical property studies of tablets, and in-vitro release kinetics studies. The USP apparatus type II was selected to perform the dissolution test, and the dissolution medium was 900 mL phosphate buffer pH 6.8. The test was carried out at 75 rpm, and the temperature was maintained at 37oC ± 0.5oC.
License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author Information

# Name Institute / Affiliation
1 S.Rohini Reddy Surabhi DayakarRao College of Pharmacy
2 CH.Shanthi Priya Surabhi DayakarRao College of Pharmacy
3 Dr M Venkata Ramana Surabhi DayakarRao College of Pharmacy
4 M.Praveen Surabhi DayakarRao College of Pharmacy
5 K.Srikanth Surabhi DayakarRao College of Pharmacy
6 G.Srinivas Surabhi DayakarRao College of Pharmacy
7 CH.Vaishnavi Surabhi DayakarRao College of Pharmacy
8 G.Suchitha Surabhi DayakarRao College of Pharmacy

How to Cite

Use the following formats to cite this article in your research.

APA Style
Reddy, S.Rohini, Priya, CH.Shanthi, Ramana, Dr M Venkata, M.Praveen, K.Srikanth, G.Srinivas, CH.Vaishnavi, & G.Suchitha (2022). Formulation and Evaluation of Sustained Release Tablets of Losartan Potassium. International Journal of Advance Research and Innovative Ideas In Education, 8(4), 378-382.
MLA Style
Reddy, S.Rohini, et al. "Formulation and Evaluation of Sustained Release Tablets of Losartan Potassium." International Journal of Advance Research and Innovative Ideas In Education, vol. 8, no. 4, 2022, pp. 378-382.
IEEE Style
S.Rohini Reddy, CH.Shanthi Priya, Dr M Venkata Ramana, M.Praveen, K.Srikanth, G.Srinivas, CH.Vaishnavi, and G.Suchitha, "Formulation and Evaluation of Sustained Release Tablets of Losartan Potassium," International Journal of Advance Research and Innovative Ideas In Education, vol. 8, no. 4, pp. 378-382, 2022.
Vancouver Style
Reddy S.Rohini, Priya CH.Shanthi, Ramana Dr M Venkata, M.Praveen, K.Srikanth, G.Srinivas, et al. Formulation and Evaluation of Sustained Release Tablets of Losartan Potassium. International Journal of Advance Research and Innovative Ideas In Education. 2022;8(4):378-382.
Harvard Style
Reddy, S.Rohini, Priya, CH.Shanthi, Ramana, Dr M Venkata, M.Praveen, K.Srikanth, G.Srinivas, CH.Vaishnavi, & G.Suchitha (2022) 'Formulation and Evaluation of Sustained Release Tablets of Losartan Potassium', International Journal of Advance Research and Innovative Ideas In Education, 8(4), pp. 378-382.
Chicago Style
Reddy, S.Rohini, et al. "Formulation and Evaluation of Sustained Release Tablets of Losartan Potassium." International Journal of Advance Research and Innovative Ideas In Education 8, no. 4 (2022): 378-382.
Turabian Style
Reddy, S.Rohini, et al. "Formulation and Evaluation of Sustained Release Tablets of Losartan Potassium." International Journal of Advance Research and Innovative Ideas In Education 8, no. 4 (2022): 378-382.

Export Citation