LIQUISOLID TECHNIQUE: AN APPROACH FOR ENHANCEMENT OF DISSOLUTION

PHARMACY

The liquisolid system is a novel delivery system for drugs via the oral route. Increasing the solubility of low-aqueous-soluble drugs and lipophilic drugs can be accomplished with this technique. The medication could be in a solid dosage form that is held in solution inside the powder substrate, or it could be in a solubilized, virtually molecularly disseminated condition. As a result, their wetting qualities and drug surface area available for dissolution are greatly increased. It is expected that liquisolids containing water-insoluble substances would enhance the drug release properties and ultimately increase the bioavailability. The liquisolid tablets are prepared by dissolving the drug in a non-volatile solvent with suitable carrier and coating materials. A Liquisolid system is formed by mixing these components and subjected to a direct compression process for tableting. Liquisolid systems can be obtained with a sustained release by using hydrophobic carriers (e.g., Eudragit RL and RS) instead of hydrophilic carriers. This review's major focus is on the liquisolid technique that has been successfully used to enhance in vitro drug release of low aqueous soluble drugs.

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