INVESTIGATIONAL STUDIES FOR ANTIDIABETIC ACTIVITY OF ALOE BARBADENSIS LEAVES EXTRACT

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Crude aqueous and alcoholic extracts of leaves of Aloevera at a dose of 20 and 30mg/kg showed significant effect on the glucose tolerance of rats and it also showed reduction in the fasting blood glucose levels of the normoglycaemic rats, thus revealing the hypoglycaemic nature of the extracts. The effect was more pronounced for both extracts. These findings indicate that the extracts might be producing hypoglycaemic effect by a mechanism independent from the insulin secretion e.g. by the inhibition of endogenous glucose production or by the inhibition of intestinal glucose absorption. he data of the blood glucose level of rats treated with Alloxan (150mg/kg body weight) produced diabetes within 72 hours. After 72 hours of Alloxan administered the blood glucose levels of rats were observed. It was observed that significant lowering of sugar in aqueous and alcoholic extract. The administration of different extracts at a dose of 20 and 30 mg/kg showed significant anti- hyperglycaemic effect at 22nd day which was evident from the 7th day on wards as compared to standard. The aqueous and alcoholic extract of Aloevera has showed better anti- hyperglycaemic effect of the extract on the fasting blood sugar levels on diabetic rats are shown in table. The decreasing blood glucose levels are comparable with that of 10 mg/kg of Glibenclamide. The Glibenclamide (10 mg/kg body weight) shows significant effect on compare to the initial and more significant effect on the 22nd Day compare to the initial. The aqueous and alcoholic extracts of 20 and 30mg/kg body weight shows significant (P*<0.05), effect.

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