TRANSETHOSOME: A NOVEL DRUG DELIVERY THROUGH SKIN

Pharmacy

Transdermal route is one of the promising routes for delivery of drugs. The delivery of drugs through skin is still a challenge as some bioactive molecules does not pass easily through stratum corneum. The development of ultradeformable vesicles (UDV) is an improved tool for dermal and transdermal therapies. The UDV includes ethosomes, transferosomes and transethosomes. Transethosome vesicular system provides enhanced permeation of drug through stratum corneum of skin due to the presence of increased concentration of ethanol, edge activators and phospholipids. Various methods are involved in the formulation of transethosomes such as hot method, cold method, thin film hydration method, reverse phase evaporation, transmembrane pH gradient method, ethanol injection method. Due to deformable characteristics of vesicular system results in increased drug entrapment efficiency, permeation and penetration of drug into the deeper layer of skin. The characterization of the vesicles include morphology of transethosomes, particle size and zeta potential, entrapment efficiency, transition temperature, drug content, vesicle stability, skin permeation studies, measurement of elasticity. These vesicular systems can be used for transdermal delivery of various drugs like antiviral, antibiotics, analgesic, anticancer, anti-arthritis etc.,

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.