A NOVEL APPROACH: FLOATING DRUG DELIVERY SYSTEM.

PHARMACY

The Gastroretentive drug delivery system (GRDDS) is the novel approach of retaining dosage form in stomach after oral administration and to ensure release of the drug in a controlled and prolonged manner, to its absorption sites in gastric region. The drug which shows characteristic property in acidic media or upper part of gastrointestinal tract mainly in the gastric region, are most suitable candidate for such gastro retentive dosage form. The drugs which have short half-life can remain for several hours and gives prolong gastric residence time of drugs and significantly enhances absorption. Mechanism behind the principle of floating is density, bulk density in floating drug delivery system (FDDS) is more than the gastric fluids and therefore, they remain buoyant or float in the stomach for a prolong period without disturbing gastric emptying rate. and resulting into increased in gastric residence time and a good control of plasma drug concentration. The main purpose of this paper is to review the concept of gastroretentive drug delivery systems with the recent literature and advanced technology used in the development of this system.

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