Formulation And Evaluation of Ofloxacin Loaded Floating Microballons

Pharmacy

The present study involves preparation and evaluation of floating microballoons of Ofloxacin for improving the bioavailability by prolongation of gastric residence time in GIT. Ofloxacin, a sparingly water-soluble drug, was selected and microballoons were prepared by emulsion solvent diffusion method using Eudragit RS-100, CAP as a polymer, in ethyl alcohol and dichloromethane organic solvent system. The formation of a sphere and hollow within the sphere was confirmed through SEM studies. The percentage of drug entrapment and recovery was found to be 75- 80%. The micromeritic properties indicated better flowability and packability of the spheres. The Buoyancy test showed good floatability of Ofloxacin microballoons in the simulated gastric fluid for more than 24 h. In vitro dissolution profile showed prolonged release of drug from the formulations. Thus, microballoons of Ofloxacin with acrylic polymers prepared by emulsion solvent diffusion method show to be an ideal novel floating dosage form that is adaptable to any intragastric condition for controlled drug delivery and enhanced bioavailability.

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