FORMULATION DEVELOPMENT AND EVALUATION OF pH BASED INSITU VAGINAL GEL OF SECNIDAZOLE for vaginal delivery

April 2021
Vol-7, Issue-2
Paper ID: 14021
ISSN: 2395-4396
Downloads: 0

Abstract & Details

Research Area
Pharmaceutical
Keywords
secnidazole antibacterial insitu gel Carbopol 934 local action Invitro-diffusion
Abstract
The aim of the study was to formulate and develop the insitu gel of secnidazole for vaginal route. Secnidazole is a second generation antibacterial drug with fewer side effects than other antibacterial drug. Present formulation is prepared to provide local action. With the help of pH triggered system, the present formulation convert from solution to gel when change occur from normal pH (3.5-4.5) .The insitu gel is prepared by using Carbopol 934 as pH sensitive agent and HPMC K-100M as Mucoadhesive agent. The preliminary trials were performed by using polymer of various concentrations of guar gum, Xanthan gum and Carbopol 934.The preliminary batches were studied for gelation property and selection of polymer is done. The prepared formulations were then evaluated for visual appearance, pH measurement, rheological studies, clarity, gelling capacity and drug content.
License
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Author Information

# Name Institute / Affiliation
1 Patel Alexkumar Mansukhlal B.N.B Swaminarayan Pharmacy Colleg
2 Narkhede Kantilal B B.N.B Swaminarayan Pharmacy Colleg
3 Prajapati Anuradha P B.N.B Swaminarayan Pharmacy Colleg
4 Narkhede Sachin B B.N.B Swaminarayan Pharmacy Colleg

How to Cite

Use the following formats to cite this article in your research.

APA Style
Mansukhlal, Patel Alexkumar, B, Narkhede Kantilal, P, Prajapati Anuradha, & B, Narkhede Sachin (2021). FORMULATION DEVELOPMENT AND EVALUATION OF pH BASED INSITU VAGINAL GEL OF SECNIDAZOLE for vaginal delivery. International Journal of Advance Research and Innovative Ideas In Education, 7(2), 1229-1239.
MLA Style
Mansukhlal, Patel Alexkumar, et al. "FORMULATION DEVELOPMENT AND EVALUATION OF pH BASED INSITU VAGINAL GEL OF SECNIDAZOLE for vaginal delivery." International Journal of Advance Research and Innovative Ideas In Education, vol. 7, no. 2, 2021, pp. 1229-1239.
IEEE Style
Patel Alexkumar Mansukhlal, Narkhede Kantilal B, Prajapati Anuradha P, and Narkhede Sachin B, "FORMULATION DEVELOPMENT AND EVALUATION OF pH BASED INSITU VAGINAL GEL OF SECNIDAZOLE for vaginal delivery," International Journal of Advance Research and Innovative Ideas In Education, vol. 7, no. 2, pp. 1229-1239, 2021.
Vancouver Style
Mansukhlal Patel Alexkumar, B Narkhede Kantilal, P Prajapati Anuradha, B Narkhede Sachin. FORMULATION DEVELOPMENT AND EVALUATION OF pH BASED INSITU VAGINAL GEL OF SECNIDAZOLE for vaginal delivery. International Journal of Advance Research and Innovative Ideas In Education. 2021;7(2):1229-1239.
Harvard Style
Mansukhlal, Patel Alexkumar, B, Narkhede Kantilal, P, Prajapati Anuradha, & B, Narkhede Sachin (2021) 'FORMULATION DEVELOPMENT AND EVALUATION OF pH BASED INSITU VAGINAL GEL OF SECNIDAZOLE for vaginal delivery', International Journal of Advance Research and Innovative Ideas In Education, 7(2), pp. 1229-1239.
Chicago Style
Mansukhlal, Patel Alexkumar, et al. "FORMULATION DEVELOPMENT AND EVALUATION OF pH BASED INSITU VAGINAL GEL OF SECNIDAZOLE for vaginal delivery." International Journal of Advance Research and Innovative Ideas In Education 7, no. 2 (2021): 1229-1239.
Turabian Style
Mansukhlal, Patel Alexkumar, et al. "FORMULATION DEVELOPMENT AND EVALUATION OF pH BASED INSITU VAGINAL GEL OF SECNIDAZOLE for vaginal delivery." International Journal of Advance Research and Innovative Ideas In Education 7, no. 2 (2021): 1229-1239.

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