PYRIDOXINE INDUCED PERIPHERAL NEUROPATHY A DETAILED REVIEW

pharmaceutical sciences

Vitamin B6, also known as pyridoxine, is a water-soluble vitamin that the body needs for several important functions. It is significant to protein, fat, and carbohydrate metabolism and the creation of red blood cells and neurotransmitters. Pyridoxine (vitamin B6) is a co-factor in many enzymatic pathways involved in amino acid metabolism. It is also recommended as a co-factor to improve the conversion of glyoxylic acid into glycine in ethylene glycol poisoning. Pyridoxine is active in its phosphorylated form of pyridoxal-5-phosphate. Peripheral neuropathy refers to the conditions that result when nerves that carry messages to and from the brain and spinal cord from and to the rest of the body are damaged or diseased. Although the family of B vitamins is often non-toxic, high doses of pyridoxine cause peripheral sensory nerve damage. There are some case reports of sensory neuropathies at doses of less than 500 mg per day in patients taking supplements for months. However, none of the studies had sensory nerve damage at daily intake below 200 mg pyridoxine per day.Thus, intake of doses greater than 100-300mg/d or even 50 mg/d used for longer than 6 months would be deemed harmful.

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