FORMULATION AND EVALUATION OF DIPHENHYDRAMINE MEDICATED CHEWING GUM

Pharmacy

The release of a drug from chewing gum is dependent upon its water solubility. Water soluble substances are released rapidly and completely from chewing gum and methods are available which retard their release from chewing gum to provide an extended release profile. An attempt has been made to formulate new chewing gum device for Diphenhydramine in the form of tablet. Drug release from a dosage form is the critical step in drug absorption and bioavailability, thus an experimental work has been designed to evaluate the efficiency of this kind of therapeutic system by verifying its capability to release the drug dose and by assessing the delivery of Diphenhydramine for by passing the hepatic first pass effect. Different formulations of chewing gum with varying concentration of plasticizers like glycerol and castor oil were formulated. Better consistency of formulation and faster release of drug in saliva was obtained with glycerol P (IV), and Castor oil F (II) but castor oil shows optimum result against glycerol combination, which is formulation II. Urinary excretion profile showed that within the short span of time 1.5 h drug was excreted. Buccal absorption test showed that 80% of drug absorbed within 10 min when available to the buccal mucosa at pH 5.5.

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