EVALUATION OF IN-VIVO ANTIDIABETIC ACTIVITY OF POLYHERBAL EXTRACT

Pharmacy

The main aim of the work is to determined the anti-diabetic activity of mixture of hydroalcoholic extracts of Phyllantus emblica (Friuts), Annona reticulata (leaves), Ceasalpinia bonducella (seeds) were collected from local area, dried, pulverized and extracted with etanol and water (7:3). Anti-diabetic effect of extract was studied by using metformin as a standard on alloxan induced diabetic rats. There were six groups of animal in that I was normal ,II was Control ,III was standard. There were a three combination of mixture of extracts were administered to group IV ,V,VI after that blood sugar levels were measured at 0,2,4,8,16,24,32 hrs respectively by taking blood at retro orbital route with the help of accu check active glucometer. Results: Significant lowering of blood sugar was observed after administration of combination I(Phyllantus emblica (100mg), Annona reticulata (100mg), Ceasalpinia bonducella (100mg) of mixture of extracts Conclusion: combination of mixture of Phyllantus emblica (Friuts), Annona reticulata (leaves), Ceasalpinia bonducella (seeds) shows significant antidiabetic activity.

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