MIXED GONADAL DYSGENESIS: A CASE REPORT

Medical Science

A 16-year-old girl came to the Gynecology Polyclinic at Haji Adam Malik General Hospital, Medan, complaining of primary amenorrhea. The patient never experienced cyclical abdominal pain or enlargement or lump in the abdomen. Breast growth is found to be in Tanner stage III and pubic hair growth is in Tanner stage II. The patient’s height is lower compared to women of her age. The patient weighs 43 kg and is 135 cm tall. Laboratory tests revealed increased levels of FSH, LH, and estrogen. Testosterone levels are within the normal range. Transrectal ultrasound examination revealed uterine hypoplasia with anteflexed uterine position measuring 25.8 x 20.1 x 10.9 mm. The thickness of the endometrium and the left and right ovaries is difficult to assess. The patient then underwent a pelvic MRI examination and found a reduction in the uterus with a volume of 3.43 x 5.54 x 1.45 x 0.523 x 16.69 cm. The endometrium appears to have irregular border. The patient is then planned to carry out a karyotyping examination. From the results of the examination, it was found that the karyotype was 45X / 46 XY. This patient was then diagnosed with mixed gonadal dysgenesis (MGD) and managed with combined contraceptive pills for 3 months.

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