DESIGN AND DEVELOPMENT OF POLYMERIC NANOPARTICLES LOADED IN HYDROGEL OF MICONAZOLE FOR FUNGAL TREATMENT

Pharmaceutical

Miconazole is one of the broad spectrum antifungal compounds of the imidazole group. In Present investigation chiosan nanoparticles of Miconazole was prepared and evaluated for Percentage yield, Drug entrapment, Zeta potential and particle size and further prepared nanoparticles incorporated in gel base and evaluated. Percentage yield of different formulation was determined by weighing the nanoparticles after drying. The optimized formulation among other batches subjected to further studies.The results of measurement of mean particle size of optimized formulation F2 nanoparticles were found 85.6 nm. Gel preparation corresponding to 2.0% w/w (2.0 mgof drug in 100 mg of gel) of drug was incorporated into the gel base to get the desired concentration of drug in gel base.Gels were evaluated by means of pH, spreadability, viscosity and drug content and extrudability. pH was determined using digital pH meter.The viscosity of gels was determined by using a Brookfield viscometer DV-II model. It was concluded that prepared gel containing Miconazole nanoparticles was optimized and successfully formulated in the form gel can be use for topical preparation for antifungal effect.

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