ANTIHYPERLIPIDEMIC ACTIVITITY OF MEDICINAL PLANT IN HIGH FAT DIET INDUCED HYPERLIPEMIA IN EXPERIMENTAL ANIMAL

M.pharm in Pharmacology

Objective: The present study is an attempt to investigate its anti-hyperlipidemic activity of ethanolic extract of Flemingia Strobilifera (EEFS) using high-fat diet (HFDs) induced hyperlipidemia. Methods: EEFS was evaluated for anti-hyperlipidemic activity in HFD induced hyperlipidemic rats. A comparison was also made between the action of Flemingia Strobilifera extract and a known anti-hyperlipidemic drug atorvastatin (10 mg/kg body weight). The results of the study were expressed as mean ± standard error, and data were analyzed using two-way analysis of variance test followed by tukkey’s test for multiple comparisons. Values of p<0.0001 were considered as significant significant anti-hyperlipidemic activity and hence it could be a potential herbal medicine as an adjuvant with existing therapy for the treatment of hyperlipidemia. Results: Oral administration of 200, 400 mg/kg body weight of the EEFS exhibited a significant reduction (p<0.01) in serum lipid parameters such as total cholesterol, triglycerides, low-density lipoprotein (LDL), very LDL, and increase in high-density lipoprotein (HDL)in hyperlipidemic rats of both models as compared to hyperlipidemic control statistically. These extracts were found to possess better anti-hyperlipidemic potential. Conclusion: Our results demonstrated that MESA bark possessed significant antihyperlipdemic activity.

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