THE ROLE OF PIPER LONGUM IN OVARIAN-METABOLIC MODULATION

pharmacy

Piper longum (Indian long pepper) is a well-known medicinal plant used extensively in traditional systems such as Ayurveda for its diverse therapeutic properties. This study investigates its role in managing Polycystic Ovary Syndrome (PCOS) and Polycystic Ovarian Disease (PCOD). Ethanol-based Soxhlet extraction of Piper longum was performed to obtain a phytochemically rich extract, which was subjected to ash value, extractive value, and phytochemical screening. Techniques such as Thin Layer Chromatography (TLC), paper chromatography, and GC-MS were employed to identify major constituents like piperine, caryophyllene, glycerin, and heptadecane. The extract demonstrated antioxidant, anti-inflammatory, insulin-sensitizing, and hormone-regulating properties—mechanistically aligning with key pathological features of PCOS/PCOD. A polyherbal syrup formulation including Piper longum, Shatavari, and Ashwagandha was developed and evaluated. The study supports the potential of Piper longum as a complementary therapy for managing PCOS/PCOD through multiple pharmacological pathways.

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