The diagnosis of cholangiocarcinoma

Medical

Background The most frequent primary hepatic malignancy is cholangiocarcinoma (CCA). Wide resections, the development of local treatment, and chemotherapy have all improved the prognosis in recent years. Objective To determine the diagnosis of cholangiocarcinoma Methods A cross-sectional study was conducted at Gulab hospital, Lahore, Pakistan which was performed between June 2023 to Feburary 2025, The total number of patients in our study were 100. The number of Male patients in our study were 55 and female were 45. For all patients, we did diagnostic tests, (CA-19-9), (MRCP, CT Scan). We also took stages of cholangiocarcinoma. We took parameters of BMI (kg/m2) for all patients. We excluded pregnant women and children in our study. Data was tabulated and analyzed by SPSS version 27. Results In a current study total 100 patients were enrolled. The minimum age of patients were 53 years and the maximum age of the patients were 78 years. The mean age were 65.10±7.752 years. The minimum BMI of patients were 23 (kg/m2) and the maximum BMI 39 (kg/m2). The minimum ALT were 73 and the maximum were 105 (u/l). The minimum AST were 60 and the maximum were 96 (u/l). The minimum ALP were 140 and the maximum were 250 (u/l).The mean of ALP were 181.80±24.96 (u/l).The frequency of Jaundice were not present in 30 patients and were present in 70 patients. The frequency of Itchy skin were not present in 65 patients and were present in 35 patients. The frequency of dark urine were not present in 80 patients and were present in 20 patients. In Figure 3, we can see the treatment of cholangiocarcinoma, (Biliary drainage 10%, Chemotherapy 15%, RFA 35%, and Surgery in 40% of patients).The frequency of CA-19-9 were negative in 25 patients and were positive in 75 patients. P-Value were 0.03. The frequency of diagnose of cholangiocarcinoma on CT scan were 30 and diagnose on MRCP were 70 and its percentage were 70%.In our study P-Value were less than (< 0.05). Conclusion We concluded that Cholangiocarcinoma best and early diagnosis on MRCP. Stage 2 is the most common stage of cholangiocarcinoma in the study.

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