HEPATOPROTECTIVE ACTIVITY OF SAUROPUS ANDROGYNOUS LEAVES AGAINST PARACETAMOL AND ETHANOL INDUCED HEPATOTOXICITY IN RATS.

Pharmacology

The hepatoprotective activity of ethanolic extract of the leaves of Sauropus androgynous was investigated for paracetamol and ethanol induced hepatotoxicity in rats. Wistar albino rats were divided into five groups of 6 animals each and are given orally with the following treatment for 10 and 21 days respectively. The Normal control group was given 0.3% starch solution 1 ml/kg b.w, Paracetamol at a dose of 2 g/kg b.w, p.o, and 30% Ethanol at a dose of 1 ml/100 g b.w, was given for inducing hepatotoxicity. Silymarin (50 mg/kg, p.o.) was given as reference standard for both the methods. Two doses of S. androgynous leaves extract i.e., 200 and 400 mg/kg p.o. was tested for hepatoprotective activity. The treatment was given for 10 days in Paracetamol induced hepatotoxicity and 21 days for Ethanol induced hepatotoxicity model. After 24 h of last treatment blood was collected by cardiac puncture and analysed for various serum parameters like serum glutamic pyruvic transaminase (SGPT), serum glutamic-oxaloacetic transaminase (SGOT), alkaline phosphatase (ALP), total protein (TP) and total bilirubin (TB) in different groups. In both the methods, ethanolic extract of Sauropus androgynous showed dose dependent significant decrease in SGPT, SGOT, ALP, total bilirubin and increase in total protein levels. Hepatoprotective effect was also confirmed by histopathological studies of liver which showed less damage in extract treated groups when compared with Paracetamol (2 g/kg) and 30% Ethanol (1 ml/100g). The extract found to have significant hepatoprotective activity in both Paracetamol and Ethanol induced hepatic injury models.

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