Spherical Crystallization of Depsone To Improve PhysicoChemical and Micromeritics Properties.

Pharmacy

In 1986, Kawashima pioneered the spherical crystallization technique for enlarging the size of drugs in the field of pharmacy. This innovative approach aimed to enhance the flow and compressibility characteristics of microcrystalline drug candidates. The process of spherical crystallization involves utilizing agglomerating solvents, quasi-emulsion solvent diffusion, and ammonia diffusion techniques. Optimization of temperature and agitation speed is crucial to achieve spherical agglomerates within the desired range, which is essential for improving compressibility. The resulting spherically agglomerated crystals can be directly prepared into tablet form or compounded into pharmaceutical systems without the need for additional processing such as granulation. Spherical crystallization serves as a particle design technique, enabling simultaneous crystallization and agglomeration in a single step. It has proven effective in enhancing the flowability and compatibility of crystalline drugs. Characterization of spherical crystals typically involves Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), and X-ray diffraction (XRD) to assess any physicochemical interactions between the drug and carrier that could impact dissolution. Additionally, the solubility of the crystals is evaluated to ascertain their performance.

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