ANTIUROLITHIATIC AND ANTIMICROBIAL ACTIVITY OF SYNTHESIZED ZINC NANOPARTICLES USING VILVAM MEDICINAL PLANTS ON URINARY TRACT INFECTION CAUSING STRUVITE URINARY STONES

Biomedical Engineering

Urinary tract infections (UTIs) represent a significant health concern globally, often accompanied by the formation of urinary stones, particularly struvite stones. In this study, we synthesized zinc nanoparticles (ZnNPs) using extracts from Vilvam (Aegle marmelos), a medicinal plant renowned for its antimicrobial properties. We evaluated the potential of these nanoparticles as antiurolithiatic and antimicrobial agents against struvite urinary stones associated with UTIs. The green synthesis of ZnNPs was achieved through the reduction of zinc salts using Vilvam leaf extract. Characterization of the synthesized nanoparticles was conducted using UV-,and Fourier-transform infrared spectroscopy (FTIR). Antiurolithiatic activity was assessed by determining the ability of ZnNPs to inhibit the formation and growth of struvite crystals in simulated urine. Results demonstrated significant inhibition of struvite crystal formation in the presence of ZnNPs compared to control groups. In conclusion, the synthesized ZnNPs using Vilvam extracts show promising antiurolithiatic and antimicrobial activities against struvite urinary stones and UTI-causing pathogens.

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