FORMULATION AND EVALUATION OF SUSTAINED RELEASE ANASTROZOLE TABLET FOR TREATMENT OF BREAST CANCER

B - Pharmacy

Breast cancer is the major global health concern and second most common cancer in women. While breast cancer can also occur in men, but it is much less common. Early detection and treatment are important for improving the outcome of breast cancer. The past decade has gain significant advancements in both understanding breast cancer and developing preventative methods. The most common preventive method is the chemotherapy which including various types of medication. Anastrozole is a nonsteroidal drug and act as selective aromatase inhibitor, which plays a crucial role in endocrine therapy for certain hormone sensitive breast cancers. However, treatment with conventional tablets of anastrozole drug may have limitations such as frequent dosing, fatigue, muscle and joint pain, nausea, hot flashes and potential side effects. This study aimed to develop and evaluate a novel formulation of anastrozole tablets to minimize this serious adverse effect of conventional oral formulation.

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