Enhancement of solubility and dissoulation of a drug Mefenamic acid

Pharmacy

Mefenamic acid is a poorly water-soluble drug (BCS Class II), widely prescribed formild to moderate pain, primary dysmenorrheal, rheumatoid arthritis, osteoarthritis and otherjoint diseases.Inorder to increase its solubility and dissolution rate, various solubilityenhancement methods like solvent evaporation, trituration, ball milling, physical mixing andnon-solvent methods in chitosan carrier, with different mefenamic acid to chitosan ratioshave been investigated. Drug-carrier interactions were investigated by differential scanningcalorimetry and FT-IR spectroscopy. The studies showed that solubility and dissolution rateof mefenamic acid were distinctively increased in the prepared binary mixture compared tothat of pure mefenamic acid. The increase of dissolution rate was related to the ratio ofmefenacmic acid to chitosan and the method employed.Cogrinding methods (Triturationand ball milling) were the most effective techniques, showing the strongest amorphizingeffect of chitosan. The drug-carrier binary mixtures (Mefenamic acid- chitosan = 1:10 w/w)gave the highest dissolution rate, i.e., about 19.2-fold higher than that of the pure mefenamic acid.

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