TEST EFFECT OF CREAM PREPARATIONS OF RED BETEL LEAF EXTRACT (Piper crocatum Linn.) IN ACCELERATING THE HEALING OF CUT WOUNDS IN MALE WISTAR RATS

Clinical Medicine

The wound healing process can be divided into three main phases, namely, the inflammatory phase, the proliferation phase, and the remodeling phase. In red betel leaves, phytochemical compounds are contained: alkaloids, saponins, tannins, and flavonoids. The content of flavonoids as immunostimulants and saponins can be a cleanser and antiseptic that kills or prevents the growth of microorganisms that usually arise in wounds so that wounds do not experience severe infections. The study aims to develop nano herbal red betel leaves as an active ingredient in preventing cut injuries on the skin. This type of research is experimental, with a Pre-test and Post-test group-only control design approach carried out in March 2022; the entire study was carried out at the USU Pharmaceutical Pharmacology Laboratory. Determination of sample size according to Frederer's formula, with a minimum sample number of 5 mice for each group. Red betel extract contains alkaloid chemical compounds, flavonoids, saponins, and tannins. The wound recovery rate per day, from day 1 to day 7, the wound recovery rate is still linear. Still, on the 9th to the 14th day, there is a decrease in the cure rate at a concentration of 7% compared to treatment at a concentration of 5% and far behind when compared to those given Bioplacenton®. The conclusion of the optimum concentration of red betel ethanol extract that can heal cut wounds in white rats is 5%. The highest recovery percentage on k-14 days was in a positive control (Bioplacenton®), which was 95%, followed by extracting 5% v /v with a cure percentage of 90%. Gel preparations of red betel ethanol extract have an ability close to Bioplacenton® in healing cut wounds in rats

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