Effectiveness Test of Antioxidant and Antibacterial Activities of Turmeric (Curcuma Longa Linn.)

Clinical Medicine

Research on Turmeric (Curcuma longa Linn.) is essential in evaluating antibacterial effects against Staphylococcus epidermidis, especially in biofilm formation. One interesting approach is the development of curcumin nanoparticles, as they can enhance antibacterial activity. The methods used in this study include turmeric collection and processing, simplistic making, ethanol extraction, as well as testing antioxidant activity with DPPH method (1,1-diphenyl-2-picrylhydrazil) and antibacterial activity with minimum inhibitory concentration method (KHM). The results showed that turmeric ethanol extract effectively inhibited the growth of Staphylococcus epidermidis, especially at concentrations of 300 mg / mL with an average inhibitory zone diameter reaching 10.12 mm. The negative control shows a consistent inhibitory zone at 6.00 mm. Antimicrobial compounds, particularly flavonoids in turmeric extract, damage protein structures and bacterial cell membranes, resulting in bacterial cell death. These results provide a deeper understanding of turmeric extract’s potential as an effective antibacterial agent against Staphylococcus epidermidis. In addition, turmeric ethanol extract also showed significant antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis at various concentrations, with the largest inhibition zone at 300 mg/mL. Nonetheless, more research is needed to understand the mechanism of action and potential side effects in greater depth. Thus, turmeric has the potential to be an exciting alternative in the development of natural antibacterial agents that are effective and safe to use in clinical practice

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