Antiurolithiatic activity of Coffea arabica seed extract

Pharmacology

Evaluated the antiurolithiatic activity of Coffea arabica seed extract in validated experimental animal models. The antiurolithiatic activity of Coffea arabica seed extract in Ethylene Glycol and Sodium Oxalate induced animals. Preliminary phytochemical screening was carried out for Coffea arabica seed extract. The parameters like body weight, kidney weight, urine analysis, serum analysis and histopathology of kidney were studied. Ethylene Glycol and Sodium Oxalate administration resulted in hyperoxaluria as well as increased excretion of calcium, oxalate, phosphate and potassium. Treatment with Coffea arabica seed extract produced significant reduction of excretion of calcium oxalate in ethylene glycol and sodium oxalate induced animals. Treatment with Cystone 750mg/kg and Coffea arabica (low dose 100mg/kg, high dose 250mg/kg) increases the level of magnesium in ethylene glycol and sodium oxalate animals. Magnesium level which helps in prevent the formation of calcium oxalate crystals in ethylene glycol and sodium oxalate induced urolithiatic animals. Coffea arabica seed extract (low dose 100mg/kg, high dose 250mg/kg) significantly reduces the activity of calcium oxalate in the kidney indicates the reduction of stone formation. The present study concluded that Coffea arabica seed extract was found to be effective against reduction of stone formation induced by ethylene glycol and sodium oxalate.

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