Phytochemical, Antioxidant and Hepatoprotective Activity of Parkia biglobosa Husk Methanol Extract in Albino Rats.

Biochemistry

Abstract Medicinal plants are used in almost every part of world to treat illnesses. Oxidative stresses are known to cause damage to living system of humans and animals.This study assessed the determination of phytochemical constituents present in Parkia biglobosa husk, antioxidants and hepatoprotective effect of husk methanol extract on rats .The phytochemical property of methanol extract was determined using standard methods. The phytochemical screening of the husk methanol extract revealed the presence of alkaloid, saponins, tannins, flavonoids, steroids and glycosides. The quantitative phytochemical analysis revealed high content of tannins 42.8%, flavonoids 35.5%, steroids 32.6%, alkaloids 16%, saponins 14.5% and glycosides 3.2%. The oxidative stress markers as SOD, CAT, GSH, Vit C, and Vit E were increased significantly (P < 0.05) at 50mg/kg, 100mg/kg, 150mg/kg and 200mg/kg of Husk extract of P. biglibosa treated animals and decreased significantly the MDA level as compared to control group.Treatment of animals with methanol husk extract at 50mg/kg, 100mg/kg, 150mg/kg and 200mg/kg exhibited significant hepatoprotection in rats induced with CCl4 compared to CCl4 untreated group. These results suggest that, the husk methanol extract of the plant posses therapeutic potentials in the treatment of liver disease.

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