Evaluation of Anti-depressant Activity of Actaea Racemosa root in Reserpine-induced experimental animal model

Pharmacology

Background: Mental health has always been a Prime importance along with physical health by the World Health Organization (WHO). Depression contributes to Significant disease burden at global level and is ranked by WHO as the single largest contributor to global disability. Actaea racemosa is known for menopausal properties, hence, this study has been conducted to evaluate the antidepressant activity of Actaea racemosa root extract in rodent models. Materials and Methods: Actaea racemosa root extract was used for evaluating the Antidepressant activity in Swiss Albino Mice. Antidepressant activity was evaluated by comparing with the positive control group by performing Forced swim test and Tail suspension test with Imipramine (10mg/kg) as the standard drug. Reserpine is used as an inducing agent. The Data was analyzed using one way ANOVA (analysis of variance) Followed by Dunnett’s Multiple Comparison Test. P value <0.0001 was considered as statistically significant. Results: Forced swim test and Tail suspension test showed Significant decrease in the period of immobility by Actaea racemosa treated groups indicating its antidepressant property. There is no significant difference observed between the two doses of the extract i.e.; 20mg/kg and 30mg/kg. Conclusion: This study shows that extract of Actaea racemosa root extract possess significant antidepressant properties. The effect produced by the two doses of the test drug was compared with the standard drugs Imipramine and along with the plain control adopting appropriate statistical analysis.

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