World of Cinnolines: A Mini Review

Pharmacy

Cinnolines is one of the most interesting heterocyclic nucleus rings which have been used so far with its usage in magnificent biological activities. Its condensed bicyclic aromatic heterocyclic contains two nitrogen atoms. Cinnolines exhibit a wide range of biological activities such as anticancer, antimicrobial, antiviral properties and many more. Derivatives of cinnoline have shown promise as kinase inhibitors, which are important targets for anticancer therapy. Furthermore, cinnoline derivatives have also demonstrated activity against several viruses, including the hepatitis B virus and influenza virus. Cinnoline derivatives have also been investigated for their potential use in the treatment of infectious diseases. In addition to their potential as drugs, cinnolines have also been studied for their use in material science. One of the challenges in the synthesis of cinnolines is the low regioselectivity of many of the reactions used to prepare these compounds. This article provides an overview of recent developments and pharmacological advances of cinnolines that has been studied over a long period of time since it has been introduced to the world. Its pharmacological developments have also been studies from last ten years which has shown wide biological advancements. However, several new methods have been developed in recent years to address this. Overall, cinnolines represent an exciting area of research with promising applications in both chemistry and biology.

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