Analysis Of Mangosteen Peel Ethanol Extract (Garcinia Mangostana L.) Against The Effectiveness Of Anti-Dyslipidemia In Male Rats Fed A High-Fat Diet

Clinical Medicine

Data in Indonesia (Riskesdas) in 2013 showed that there were 35.9% of the Indonesian population aged ≥ 15 years with abnormal cholesterol levels of a very high proportion of LDL (≥ 190 mg/dl), 22.9 % had HDL levels that were less than 40 mg/dl, and 11.9% with very high triglyceride levels (≥ 500 mg/dl). Mangosteen peel contains an organic compound, namely xanthones, known as anti-inflammatories and antioxidants that are strong and thought to be analgesics. Therefore, researchers are interested in exploring the effectiveness of anti-dyslipidemia from mangosteen peel extract. This study was experimental with a pre-and Post-test group-only control design approach using male Wistar rats as animals. This research was conducted in April 2022 at the Medanese Herbarium FMIPA USU, the Pharmacognosy Laboratory of the USU Faculty of Pharmacy, and the USU Pharmaceutical Pharmacology Laboratory. Mangosteen peel ethanol extract results contain several phytochemical compounds, including Alkaloids, Saponins, Flavonoids, Tannins, Steroids, and Terpenoids. Ethanol extract from mangosteen fruit peel significantly decreased total Cholesterol (P-value < 0.05), lowered triglyceride levels (P-value = 0.029), fell LDL levels (P-value < 0.05), and dropped SGOT levels (Value = 0.029) and SGPT (P-value < 0.05) compared to the control group. Mangosteen peel ethanol extract can also significantly increase HDL levels (P-value = 0.029)

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