A Review on Pharmaceutical Approaches On Drugs Crossing Blood Brain Barrier

Pharmacy

The blood brain barrier is a semipermeable and extremely selective system in the central nervous system of most vertebrates that separates blood from the brain extracellular fluid. It plays a vital role in regulating the transport of necessary material for brain function furthermore, protecting it from foreign substance in the blood that could damage it .The blood brain barrier (BBB) is a diffusion barrier, which impeded influx of most compounds from the blood brain. Three cellular elements of the brain microvasculature compose the BBB-endothelial cells, astrocyte end-feet, and pericyte (PCs).The blood-brain barriers playing a critical role in controlling the influx and efflux of biological substances essential for the brain’s metabolic activities as well as neuronal function. The blood-brain barrier (BBB) is a highly selective membrane barrier at the brain micro vessel level that facilities transport between the systematic circulation and the central nervous system. A growing body of the evidence supports a major role of BBB in the etiology and the pathogenesis of multiple vascular and neurodegenerative disorder.

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