FORMULATION AND EVALUATION OF TDDS OF INDOMETHACIN CONTAINING NATURAL PENETRATION ENHANCER

Pharmacy

In the present study, an attempt was made to prepare, characterize and evaluate of transdermal matrix patches of Indomethacin for inflammation and pain related disease. Based on results of various evaluation parameters like thickness, strength, elongation, better compatibility and stability the transdermal matrix patches was successfully designed and developed by trial and error method. Formulations were prepared by employing combination of HPMCK15M, PVPK30, PEG-400 and EC among penetration enhancer and patches were evaluated for uniformity of thickness, weight-variation test, folding-endurance, tensile strength, % elongation, % flatness, % moistures absorption, Moistures vapor transmittance rate, assay done. Cellophane membrane employed for the diffusion study. There were no physical changes in flexibility and physicochemical evaluation parameter was slightly changed.

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