FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF SESBANIA GRANDIFLORA EXTRACT USING NOBLE CO-PROCESS TECHNIQUE

Pharmacy

The powdered leaves and flower of Sesbania grandiflora extracted with different solvent. The resultant extract was dried in air until constant weight of the plant extract was obtained. The plant extract was then observed for the physical characteristics. Physically S. grandiflora plant extracts was blackish green in color, bitter in taste and sticky in nature. The solubility analysis of leaves and flower extract of S. grandiflora was performed by using different solvents of variable polarity. The plant extract showed good solubility in variable solvents. The extracted value of S. grandiflora was found to be 15.4. Co-processed superdisintegrants were prepared by solvent evaporation using crospovidone and croscarmellose sodium in different ratios (1:1, 1:2. & 1:3). The co-processed superdisintegrants were evaluated for their flow and compression properties in comparison with physical mixture of superdisintegrants. The angle of repose of co-processed superdisintegrants was found to be <25o which indicate excellent flow in comparison to physical mixture of superdisintegrants (>30o) due to granule formation, Carr’s index in the range of 10-15% and Hausner’s ratio in the range of 1.10-1.14. In vitro disintegration studies on the promising formulation CPF5, control (CFF1) and commercial conventional formulations (CCF) were carried out in pH 6.8 phosphate buffer. From the evaluation parameters, it was observed that 4% co-processed superdisintegrant (1:1 mixture of crospovidone and feugreek seed mucilage) was the optimum concentration for rapid tablet disintegration on the basis of the least disintegration time observed with CPF5 formulation. The superdisintegrant action of Sodium Starch Glycolate resulted in hydrophilicity and swelling which in turn causes rapid disintegration.

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.