Formulation and evaluation of topical antifungal gel of luliconazole

Pharmacy

The goal of this study was to create a luliconazole antifungal gel utilizing neem oil, tulsi oil, cinnamon oil and aloevera gel to treat fungal infections. Essential oils are utilized as an antifungal and antibacterial agent, and aloevera is used as a gelling agent . Prior to the formation of a gel, medication preformulation tests were conducted. “ Cold Mechanical Method ’’ were performed to obtained a desire antifungal gel created by different polymer ratio and using essential oils.By altering the polymer ratio, gel were created. F1, F2, F3, F4, F5 and F6 were among the gel compositions created. Then, several evaluation characteristics such as spreadability, viscosity, pH,swelling index, percentage yield, and drug content were used to determine the gel. The topical antifungal gel of luliconazole was successfully prepared utilizing neem oil, tulsi oil, cinnamon oil, and aloe vera as the gelling agent. As a result, it was established that essential oils and aloe vera gel were employed in the formulation, and excipients were chosen to ensure that the gel was compatible with luliconazole and could be used to treat a variety of conditions. By enhancing its activity as it shows synergistic effect and reduces the side effects of the drugs. The best-fitting formulation (F3) was chosen among the six batches since it meets all the requirements .

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