DEARRANGEMENT OF SOME SERUM OXIDATIVE STRESS ENZYMES AND URIC ACID IN POST MENOPAUSAL WOMEN IN ABA METROPOLIS

Medical Biochemistry

Each year, about 1.5 million women transit into menopause and most cases, it is associated with unpleasant symptoms, increases stress and therefore increase health demand for women at this stage of life. Gamma glutamyl transferase (GGT) and lactate dehydrogenase has been highlighted to be up- graded under oxidative stress. And GGT may be an early and sensitive enzyme related to oxidative stress. This study is aimed at assessing the levels of some serum enzymes Gamma glutamyl transferase, Lactate dehydrogenase and Uric acid in post-menopausal women in Aba metropolis. Hundred Female subjects (50 post-menopausal and 50 premenopausal women) were recruited for the study. Blood samples were collected from the subjects by venipuncture and for the determination of Gamma glutamyl transferase, lactate dehydrogenase and uric acid using semi-automated analyzer. Data was analyzed using statistical package for social sciences (SPSS version 21). And one-way analysis of variance (ANOVA). The results were expressed as Mean ± Standard Deviation. The significance level for the analysis was set at equal to or less than 0.05 (p=<0.05) .The result of the study showed a significant higher activity and level in Gamma glutamyl transferase and uric acid (p<0.05) in Post-menopausal women and a non-significant lower activity in the level of lactate dehydrogenase when the two studied groups were compared at (p<0.05). Equally observed, was that women above 60 (>60) had the highest mean value of Gamma glutamyl transferase, lactate dehydrogenase and uric acid. And it was observed that there was no correlation between Gamma glutamyl transferase, lactate dehydrogenase and uric acid. This study opines that menopausal women are at risk of developing physiological disorders such as gout, cardiovascular disorders and liver complications. Therefore, attention and lifestyle changes should be adhered to. Normal regular laboratory tests are necessary to identify women who are at risk of developing life-threatening disorders.

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